In a bowl, combine chicken tenderloins, buttermilk, and hot sauce. Mix well and refrigerate for at least 30 minutes or up to overnight.
In the first shallow bowl, whisk together flour, salt, pepper, garlic powder, and half the ranch seasoning.
Place beaten eggs in the second bowl. In the third bowl, combine panko with remaining ranch seasoning.
Remove chicken from buttermilk. Dredge each tender in flour mixture, then dip in egg, then coat with panko mixture. Press coating firmly. Place on wire rack and rest 5 minutes.
Heat oil in deep skillet to 350°F. Working in batches, fry tenders 3-4 minutes per side until golden brown and internal temperature reaches 165°F.
Drain on wire rack. Serve immediately with ranch dressing for dipping.
Notes
For extra crispy results, double dredge by repeating the flour-egg-panko process
Keep oil temperature consistent by not overcrowding the pan
Let breaded chicken rest before frying to help coating adhere better